Table 2.
The relationship between clinical and image characteristics of PPLs and the diagnostic yield of R-EBUS-guided TBLB detected infectious pathogens by mNGS∗.
| Variables | mNGS diagnostic | mNGS nondiagnostic | Univariate | Multivariate |
|---|---|---|---|---|
| OR P value | OR P value | |||
| Lesion size | ||||
| >3 cm | 38 (79.2) | 5 (38.5) | 6.080 0.013 | 8.757 0.067 |
| ≤3 cm | 10 (20.1) | 8 (61.5) | ||
| Distance from the chest wall | ||||
| >3 cm | 29 (60.4) | 4 (30.8) | 3.434 0.057 | |
| ≤3 cm | 19 (39.6) | 9 (69.2) | ||
| R-EBUS probe position | ||||
| Within | 34 (70.8) | 4 (30.8) | 5.464 0.009 | 17.742 0.030 |
| Adjacent to | 14 (29.2) | 9 (69.2) | ||
| Internal echoes | ||||
| Homogeneity | 35 (72.9) | 4 (30.8) | 6.058 0.005 | 8.598 0.061 |
| Heterogeneity | 13 (27.1) | 9 (69.2) | ||
| Anechoic areas | ||||
| Yes | 5 (10.4) | 8 (61.5) | 13.760 < 0.001 | 17.878 0.019 |
| No | 43 (89.6) | 5 (38.5) | ||
| Luminant areas | ||||
| Yes | 8 (16.7) | 8 (61.5) | 8 0.001 | 16.745 0.042 |
| No | 40 (83.3) | 5 (38.5) | ||
| Total cases | 48 | 13 |
PPLs, peripheral lung lesions. R-EBUS, radial endobronchial ultrasound. TBLB, transbronchial lung biopsy. mNGS, metagenomic next-generation sequencing. ∗Data are presented as no. (%) unless otherwise indicated.