Table 3.

ROC curve comparisons between CAP severity scores and admission lactate in predicting 28-day mortality.

	AUC (95% CI)	P value	Cutoff value	Sensi (%)	Speci (%)	PPV (%)	NPV (%)
CURB65	0.744 (0.685–0.802)	<0.001	3.0	75.3	61.9	41.6	87.4
CRB65	0.737 (0.675–0.799)	<0.001	3.0	56.2	83.0	54.4	84.0
PSI	0.768 (0.711–0.824)	<0.001	131	77.5	64.0	43.7	88.8
SOFA	0.795 (0.740–0.850)	<0.001	4.0	84.3	64.4	46.0	91.9
qSOFA	0.807 (0.754–0.859)	<0.001	2.0	91.0	53.8	41.5	94.3
Lactate	0.679 (0.612–0.745)	<0.001	2.0	48.3	78.1	44.3	80.7
CURB65 + lactate	0.772 (0.718–0.827)	<0.001	0.18	83.1	59.5	42.5	90.7
CRB65 + lactate	0.776 (0.719–0.833)	<0.001	0.25	68.5	77.7	52.5	87.3
PSI + lactate	0.774 (0.719–0.828)	<0.001	0.21	80.9	61.9	43.3	90.0
SOFA + lactate	0.803 (0.749–0.857)	<0.001	0.23	74.2	76.5	53.2	89.2
qSOFA + lactate	0.833 (0.786–0.881)	<0.001	0.29	64.0	87.9	65.6	87.1

ROC: area under the curve; CAP: community-acquired pneumonia; Sensi: sensitivity; Speci: specificity; PPV: positive predictive value; NPV: negative predictive value; CURB65: confusion, urea > 7 mmol/L, respiratory rate ≥ 30/min, blood pressure < 90 mmHg systolic and/or ≤60 mmHg diastolic, and age ≥ 65 years; CRB65: confusion, respiratory rate ≥30/min, blood pressure < 90 mmHg systolic and/or ≤60 mmHg diastolic, and age ≥ 65 years; PSI: pneumonia severity index; SOFA: sequential organ failure assessment; qSOFA: quick sequential organ failure assessment.