. 2020 Apr 17;24:158. doi: 10.1186/s13054-020-02875-w

Table 2.

Ventilator settings and respiratory targets utilized in the three clinical scenarios

PaO₂/FiO₂	TV (ml/kg PBW)	Highest PEEP no-IH (cmH₂O)	Highest PEEP IH (cmH₂O)	PaCO₂ no-IH (mmHg)	PaCO₂ IH (mmHg)	PaO₂(mmHg)	SpO₂(%)
1) > 300	6–8 [433(72%)] 4–6 [136(23%)] 8–10 [21(3%)] other [11(2%)]	15 [182(30%)] 10 [158(26%)] 8 [94(15%)] 5 [69(13%)] other [98(16%)]	5 [163(27%)] 10 [155(26%)] 8 [135(23%)] 15 [52(8%)] other [96(16%)]	36–40 [308(51%)] 41–45 [105(18%)] any PaCO₂* [93(16%)] 30–35 [54(9%)] 46–55 [16(2%)] other [25(4%)]	36–40 [260(43%)] 30–35 [249(41%)] 41–45 [42(8%)] 46–55 [8(1%)] any PaCO₂* [7(1%)] other [35(6%)]	81–100 [345(57%)] 55–80 [101(17%)] 101–120 [93(15%)] nmt** [44(7%)] > 120 [18(4%)]	> 95 [311(52%)] 92–94 [257(43%)] 88–91 [33(5%)]
2) 150–300	6–8 [331(61%)] 4–6 [192(36)] 8–10 [3(1%)] other [10(2%)]	15 [218(41%)] 10 [136(25%)] 8 [71(13%)] 5 [23(5%)] other [88(16%)]	10 [171(32%)] 8 [131(24%)] 5 [103(19%)] 15 [54(11%)] other [77(14%)]	36–40 [250(47%)] 41–45 [110(21%)] any PaCO₂* [91(19%)] 46–55 [35(6%)] 30–35 [34(6%)] other [20(4%)]	36–40 [262(49%)] 30–35 [176[33%)] 41–45 [54(9%)] any PaCO₂* [10(2%)] 46–55 [4(1%)] other [30(6%)]	81–100 [283(53%)] 55–80 [115(21%)] 101–120 [84(16%)] nmt** [35(6%)] > 120 [19(4%)]	92–94 [258(48%)] > 95 [228(43%)] 88–91 [50(9%)]
3) < 150	4–6 [252(53%)] 6–8 [203(42%)] 8–10 [9(2%)] other [16(3%)]	15 [239(50%)] 10 [95(20%)] 8 [37(7%)] 5 [14(3%)] other [96(20%)]	10 [158(33%)] 8 [94(20%)] 15 [91(19%)] 5 [55(11%)] other [83(17%)]	36–40 [175(37%)] 41–45 [118(25%)] any PaCO₂* [87(16%)] 46–55 [48(10%)] 30–35 [29(7%)] other [19(5%)]	36–40 [224(47%)] 30–35 [129[26%)] 41–45 [75(16%)] any PaCO₂* [15(3%)] 46–55 [9(2%)] other [29(6%)]	81–100 [218(45%)] 55–80 [151(32%)] 101–120 [61(13%)] nmt** [36(7%)] > 120 [14(3%)]	92–94 [227(47%)] > 95 [148(31%)] 88–91 [106(22%)]

PaO₂/FiO₂

TV (ml/kg PBW)

Highest PEEP
no-IH
(cmH₂O)

Highest PEEP
IH
(cmH₂O)

PaCO₂
no-IH
(mmHg)

PaCO₂
IH
(mmHg)

PaO₂(mmHg)

SpO₂(%)

1) > 300

6–8

[433(72%)]

4–6

[136(23%)]

8–10

[21(3%)]

other

[11(2%)]

[182(30%)]

[158(26%)]

[94(15%)]

[69(13%)]

other

[98(16%)]

[163(27%)]

[155(26%)]

[135(23%)]

[52(8%)]

other

[96(16%)]

36–40

[308(51%)]

41–45

[105(18%)]

any PaCO₂*

[93(16%)]

30–35

[54(9%)]

46–55

[16(2%)]

other

[25(4%)]

36–40

[260(43%)]

30–35

[249(41%)]

41–45

[42(8%)]

46–55

[8(1%)]

any PaCO₂*

[7(1%)]

other

[35(6%)]

81–100

[345(57%)]

55–80

[101(17%)]

101–120

[93(15%)]

nmt**

[44(7%)]

> 120

[18(4%)]

> 95

[311(52%)]

92–94

[257(43%)]

88–91

[33(5%)]

2) 150–300

6–8

[331(61%)]

4–6

[192(36)]

8–10

[3(1%)]

other

[10(2%)]

15 [218(41%)]

10 [136(25%)]

8 [71(13%)]

5 [23(5%)]

other [88(16%)]

[171(32%)]

[131(24%)]

[103(19%)]

[54(11%)]

other

[77(14%)]

36–40

[250(47%)]

41–45

[110(21%)]

any PaCO₂*

[91(19%)]

46–55

[35(6%)]

30–35

[34(6%)]

other

[20(4%)]

36–40

[262(49%)]

30–35

[176[33%)]

41–45

[54(9%)]

any PaCO₂*

[10(2%)]

46–55

[4(1%)]

other

[30(6%)]

81–100

[283(53%)]

55–80

[115(21%)]

101–120

[84(16%)]

nmt**

[35(6%)]

> 120

[19(4%)]

92–94

[258(48%)]

> 95

[228(43%)]

88–91

[50(9%)]

3) < 150

4–6

[252(53%)]

6–8

[203(42%)]

8–10

[9(2%)]

other

[16(3%)]

15 [239(50%)]

10 [95(20%)]

8 [37(7%)]

5 [14(3%)]

other [96(20%)]

[158(33%)]

[94(20%)]

[91(19%)]

[55(11%)]

other

[83(17%)]

36–40

[175(37%)]

41–45

[118(25%)]

any PaCO₂*

[87(16%)]

46–55

[48(10%)]

30–35

[29(7%)]

other

[19(5%)]

36–40

[224(47%)]

30–35

[129[26%)]

41–45

[75(16%)]

any PaCO₂*

[15(3%)]

46–55

[9(2%)]

other

[29(6%)]

81–100

[218(45%)]

55–80

[151(32%)]

101–120

[61(13%)]

nmt**

[36(7%)]

> 120

[14(3%)]

92–94

[227(47%)]

> 95

[148(31%)]

88–91

[106(22%)]

*If arterial pH is in range

**Adjusted to

Abbreviations: TV tidal volume, PEEP positive end-expiratory pressure, PaCO₂ partial pressure of arterial carbon dioxide, PaO₂ partial pressure of arterial oxygen, SpO₂ arterial blood oxygen saturation, IH intracranial hypertension, PBW predicted body weight, nmt neuromonitoring