Table 1.
Baseline characteristics
| Women, n = 39 | Men, n = 184 | p value | |
|---|---|---|---|
| Age | 70.1 ± 6.0 | 67.7 ± 7.3 | 0.04 |
| Education, years | 11.0 ± 2.8 | 11.4 ± 2.9 | 0.42 |
| Duration of complaints, years | 2.3 ± 1.2 | 3.5 ± 2.8 | < 0.001 |
| APOE ɛ4 carrier,n(%) | 22 (70%) | 86 (52%) | 0.08 |
| Geriatric Depression Scale (0–15) | 4 ± 3 | 4 ± 3 | 0.65 |
| Core clinical features,n(%) | |||
| Visual hallucinations, n = 222 | 23 (59%) | 69 (38%) | 0.02 |
| Parkinsonism, n = 216 | 23 (62%) | 130 (73%) | 0.28 |
| RBD, n = 156 | 11 (55%) | 99 (73%) | 0.17 |
| Cognitive fluctuations, n = 173 | 29 (94%) | 119 (84%) | 0.26 |
| Cognitive test scoresa,n = 205 | |||
| MMSE | 21 ± 6 | 23 ± 4 | 0.02 |
| RAVLT—immediate recall | − 1.94 ± 1.10 | − 2.00 ± 0.95 | 0.74 |
| RAVLT—delayed recall | − 1.80 ± 0.98 | − 1.72 ± 0.96 | 0.84 |
| VAT—12 items | − 6.20 ± 5.78 | − 4.87 ± 4.99 | 0.31 |
| TMT-Ab | − 5.47 ± 6.46 | − 4.60 ± 4.84 | 0.52 |
| TMT-B/Ab,c | − 6.93 ± 7.03 | − 5.33 ± 6.42 | 0.32 |
| Animal fluency | − 2.38 ± 1.02 | − 1.78 ± 0.99 | 0.002 |
| Biomarker status, abnormal/available,n(%) | |||
| DAT SPECT, n = 107 | 15/15 (100%) | 79/91 (87%) | 0.06 |
| CSF Aβ42 status | 30/39 (77%) | 104/186 (56%) | 0.02 |
| Abnormal Tau/Aβ42 ratio (> 0.52) | 21/38 (55%) | 55/185 (30%) | 0.002 |
Data represent mean ± SD, median [IQR] or n (%). Parkinsonism: bradykinesia, rigidity, or tremor
MMSE Mini Mental State Examination, RAVLT Raven auditory verbal learning test (Dutch version), VAT Visual Association Test, TMT Trail Making Test
aAdjusted for age and education. Data of RAVLT, VAT, TMT, and animal fluency represent z scores, based on cognitively healthy subjects
bData are inverted and log-transformed
cMissing values are imputed based on TMT-B/A ratio for n = 101