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. 2020 Apr 17;21:20. doi: 10.1186/s12865-020-00347-y

Fig. 5.

Fig. 5

Proposed model for the central role of p38 mitogen-activated protein kinase in COX-2 expression in human FDC. The paracrine or autocrine effects of PGE2 are exerted to FDC via EP2 and EP4 receptors. PGE2 promotes COX-2 expression by stimulating the activity of p38 activity and repressing that of Akt. PGs released from FDC take part in the GC reactions in a paracrine fashion to regulate important functions of lymphocytes. For example, PGE2 enhances the survival and antigen-presenting capability of GC B cells