Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
A model of AR binding to DNA in the context of ERG. (A) AR binding to ARE DNA is autoinhibited by its NTD (Left and Middle). DHT is shown as green circles. Enzalutamide (red circles) impairs AR binding to DNA (Right). (B) ERG relieves AR NTD-mediated autoinhibition and stimulates AR binding to DNA (Left and Middle), even in the presence of enzalutamide (Right).
