Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Apr 17;13:62. doi: 10.1186/s13041-020-00592-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 1 — Characterization of the running mouse model and experimental timeline. (a) Distance traveled by mice provided with running wheels for up to 36 days. Data are mean +/- S.D; n=14. The graph includes also the timeline of experiments. Vertical arrows indicate BrdU injections, evaluation of metabolome and neurogenesis, behavioral testing, and cell proliferation in the dentate gyrus (DG). Weight gain (b), food consumption (c), water intake (d), blood creatinine (e) and triglyceride levels (f) determined during the entire running and/or inactive period (n=6-12). (g) Doublecortin (DCX, a neuronal differentiation marker) protein expression in the hippocampus of the running and inactive mice as determined by immunoblotting. Upper graph, representative images, lower graph, quantitative data normalized to β-III-tubulin levels (a housekeeping protein). (h) BrdU-positive cells in the hippocampus of the running and inactive mice. (b-h) graphs represent median with min. - max.; *p < 0.05, ***p < 0.001.