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Schematic representation of Dicer proteolysis in monocytic cells. Dicer is cleaved by a constitutively activate serine protease (inhibited by AEBSF) in monocytes or undifferentiated MM6 cells. Dicer up-regulation occurs during differentiation to macrophages, by down-regulation of the serine protease activity. In MM6 cells when zymosan, LPS, or PGE2 were added together with TGF-β + 1,25diOHvitD3. In monocytes differentiated with M-CSF or GM-CSF.
