Table 2.
Description of Postmortem Brain Sections
| Block | M/F | Age (yr) | DD (yr) | Cause of death | DFT (h) | Sample type | ORO, hematoxylin score | Summary observations on ORO‐stained sections |
|---|---|---|---|---|---|---|---|---|
| 1 | F | 68 | – | Colorectal metastatic tumour | 23 | NC W, OV, R | 0, 0 | Normal white matter and cortical grey matter |
| 2 | M | 49 | – | Myocardial infarction and coronary artery thrombosis | 11 | NC W, PV, R | 0, 0 | Normal white matter and grey matter |
| 3 | F | 47 | 20 | Bronchopneumonia | 9 | MS AQ, FSv, L | 4, 3 | White matter and grey matter surrounding active plaque. ORO+ cells in blood vessel walls and parenchyma |
| 4 | F | 47 | 20 | Bronchopneumonia | 9 | MS AQ, PSv, L | 5, 4 | Large plaque with active and some subacute and chronic areas. Large perivascular cuffs. White and grey matter |
| 5 | F | 71 | 32 | Bronchopneumonia | 19 | MS SAQ, O pole Sv, L | 2, 0 | Hypocellular plaque surrounded by patchy abnormal‐appearing white matter |
| 6 | M | 53 | – | Cardiac arrest | 19 | NC W, OSv, R | 0, 0 | Normal white matter. |
| 7 | F | 37 | 10 | Bronchopneumonia | 24 | MS AQ, basal ganglia, L | 3, 3 | Large subacute plaque with perivascular cuffing; areas of grey matter |
| 8 | F | 60 | 34 | Renal failure | 24 | MS SAQ, TV, L | 2, 4 | Large subacute plaque with many large and small perivascular cuffs |
| 9 | F | 49 | 11 | Bronchopneumonia | 16 | MS CQ, F pole V, R | 0, 2 | Large chronic plaque surrounded by pale abnormal white matter |
| 10 | F | 29 | 8 | Bronchopneumonia | 11 | MS SAQ, cerebellum, R | 1, 1 | Large subacute plaque with hypercellular areas |
ORO and cuffing: Scored on a scale of 0 to 5 for ORO and haematoxylin staining; 0 is what would be expected in normal control white matter. Data is averaged from duplicate sections cut immediately before and after the serial sections cut.
DD: disease duration; DFT: time between death and sample freezing; NC: normal control; W: white matter; MS: multiple sclerosis; AQ: active plaque; SAQ: subacute plaque; V: ventricular; Sv: subventricular; F: frontal; P: parietal; T: temporal; O: occipital; R: right; L: left.