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. 2006 Jun 13;211(1):164–181. doi: 10.1111/j.0105-2896.2006.00394.x

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This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

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Dynamics of the CD8⁺ T‐cell response during sequential heterologous virus infections. This figure demonstrates the kinetics of virus growth, interferon synthesis, virus‐induced lymphopenia, T‐cell expansion and then apoptotic decline, and stability of CD8⁺ memory in mice infected with lymphocytic choriomeningitis virus. It shows the enhancement of T cells specific to cross‐reactive (cxr) and the attrition against non‐cxr epitopes after challenge with a heterologous virus, such as Pichinde virus. Reprinted, with permission, from the Annual Reviews of Immunology, Volume 22 ©2004 by Annual Reviews http://www.annualreviews.org.

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