Table 2.
Experimental models of natural killer (NK) cell trafficking
| Stimulus | Organ where NK cells are recruited | Mechanisms | Reference |
|---|---|---|---|
| Human | |||
| Granulomas in TAP2‐deficient patients | Skin lung | CCR2? | Hanna et al. (93) |
| Oral lichen planus | Oral mucosa | ChemR23 | Parolini et al. (57) |
| Hemolytic uremic syndrome | Kidney | CX3CR1 | Ramos et al. (95) |
| Psoriasis | Skin | CXCR3/CCR5 | Ottaviani et al. (20) |
| Menstruation | Uterus | CXCR3? | Sentman et al. (96) |
| Invasive trophoblasts | Decidua | CXCL12/CXCR4 | Hanna et al. (94) |
| IL‐18 | LN? | CCR7 | Mailliard et al. (74) |
| Mouse | |||
| TLR7/8 ligands, injection sc | Draining LN | CXCR3 | Martin‐Fontecha et al. (87) |
| ConA‐induced hepatitis | Blood, mobilization from spleen | CXCR3 | Wald et al. (65) |
| ConA‐induced hepatitis | Liver | CCR1 | Wald et al. (91) |
| MCMV, i.p. | Liver | MCP1/CCR2 | Hokeness et al. (83) |
| MCMV or poly(I:C), i.p. | Liver | MIP1‐a/CCR5? | Salazar Mather et al. (89) |
| Toxoplasma gondii | Liver, spleen | CCR5 | Khan et al. (85) |
| Dengue virus | Liver | CXCL10/CXCR3? | Chen et al. (82) |
| Bordetella bronchiseptica | Lung | CXCR3 | Widney et al. (66) |
| Bleomycin‐induced lung fibrosis | Lung | CXCR3 | Jiang et al. (64) |
| Intracerebral coronavirus infection | CNS | CXCL10/CXCR3? | Stiles et al. (90) |
| MOG (s.c.)‐induced EAE | CNS | CX3CR1 not CXCR3 | Huang et al., Liu et al. (67, 84) |
| None | Lung | CX3CR1 | Yu et al. (92) |
| B16‐F10 | Lung | CX3CR1 | Yu et al. (92) |
| Invasive aspergillosis | Lung | MCP1/CCR2 | Morrison et al. (88) |
| EL4 tumor cells, s.c. | Tumor site | CX3CR1 | Lavergne et al. (86) |
| HSV2 genital infection | CNS | CCR5 | Thapa et al. (25) |
Compilation of data from the literature describing the recruitment of NK cells in various organs in response to the indicated stimuli. In each case, the receptor involved is indicated in bold.
HSV, herpes simplex virus; CNS, central nervous system; MCMV, mouse cytomegalovirus; LN, lymph node.