Table 1.
Patient demographic, clinical, and tumor characteristics (N = 141)
| Patient characteristic | No. (%) or median (range) |
|---|---|
| Age at initial cancer diagnosis, y | 23.6 (18 d–80 y), n = 124 |
| <18 | 47 of 124 (38) |
| ≥18 | 77 of 124 (62) |
| Unknown | 17 |
| Sex | |
| Male | 67 of 141 (48) |
| Female | 74 of 141 (52) |
| Primary tumor site | |
| Thoracic | 71 of 140 (51) |
| Head and neck | 58 of 140 (41) |
| Bone and soft tissue* | 9 of 140 (6) |
| Other site (kidney) | 2 of 140 (1) |
| Unknown | 1 |
| Gene fusion | |
| BRD4-NUTM1 | 99 of 127 (78) |
| BRD3-NUTM1 | 19 of 127 (15) |
| NSD3-NUTM1 | 7 of 127 (6) |
| ZNF532-NUTM1 | 1 of 127 (1) |
| ZNF592-NUTM1 | 1 of 127 (1) |
| Unknown NUTM1 (fusion partner was tested, but not identified) | 9 |
| Not tested | 5 |
| Histological type | |
| Carcinoma with squamous differentiation | 46 of 138 (33) |
| Carcinoma without squamous differentiation | 75 of 138 (54) |
| Other histology | 17 of 138 (12) |
| Unknown | 3 |
| Tumor diameter at diagnosis, cm | 5.6 (0.4–16.2), n = 86 |
| Tumor diameter at diagnosis | |
| <6 cm | 46 of 86 (53) |
| ≥6 cm | 40 of 86 (47) |
| Unknown | 55 |
| Lymph node and/or organ metastasis at presentation | |
| Yes | 71 of 113 (63) |
| No | 42 of 113 (37) |
| Unknown | 28 |
| Initial treatment sequence | |
| Chemotherapy ± subsequent treatment | 41 of 112 (37) |
| Radiation ± concurrent chemotherapy ± subsequent treatment | 31 of 112 (28) |
| Surgery ± subsequent treatment | 40 of 112 (36) |
| No treatment or unknown | 29 |
| Initial response | |
| Complete or partial response | 55 of 112 (49) |
| Stable or progressive disease | 57 of 112 (51) |
| Unknown | 29 |
| Did patient ever receive radiation | |
| Yes | 85 of 117 (73) |
| No | 32 of 117 (27) |
| Unknown | 24 |
| Did patient ever receive chemotherapy | |
| Yes | 105 of 117 (90) |
| No | 12 of 117 (10) |
| Unknown | 24 |
| Did patient ever receive surgery | |
| Yes | 60 of 118 (51) |
| No | 58 of 118 (49) |
| Unknown | 23 |
| For N = 60 patients who ever received surgery | |
| Any microscopic margins involved (in any surgery) | |
| Yes | 22 of 31 (71) |
| No | 9 of 31 (29) |
| Unknown | 29 |
| Any gross residual disease postoperatively (in any surgery) | |
| Yes | 31 of 47 (66) |
| No | 16 of 47 (34) |
| Unknown | 13 |
*
Bone and soft tissue primary tumors include chest wall soft tissue, soft tissue mass, right hip bone, left scapula or shoulder, right chest soft tissue, soft tissue, occipital scalp soft tissue, iliac bone, and temporal region soft tissue mass.