Table 3.
Chromosomal Location of Frequent Gene Alterations in Barrett's Adenocarcinomas
| Chromosome | Upregulated transcripts = 242 | Downregulated transcripts = 153 | Grand total | ||||
|---|---|---|---|---|---|---|---|
| p arm | q arm | Total | p arm | q arm | Total | ||
| 1 | 15 | 20 | 35 (0.01)a | 10 | 11 | 21 (0.35) | 56 |
| 2 | 7 | 10 | 17 (0.2) | 4 | 8 | 12 (0.39) | 29 |
| 3 | 3 | 4 | 7 (0.13) | 1 | 2 | 3 (0.06) | 10 |
| 4 | 1 | 4 | 5 (0.1) | 3 | 8 | 11 (0.02) | 16 |
| 5 | 0 | 8 | 8 (0.26) | 2 | 4 | 6 (0.4) | 14 |
| 6 | 8 | 2 | 10 (0.38) | 3 | 1 | 4 (0.2) | 14 |
| 7 | 3 | 3 | 6 (0.08) | 3 | 5 | 8 (0.12) | 14 |
| 8 | 2 | 6 | 8 (0.27) | 2 | 3 | 5 (0.37) | 13 |
| 9 | 1 | 7 | 8 (0.46) | 0 | 8 | 8 (0.29) | 16 |
| 10 | 5 | 7 | 12 (0.27) | 3 | 6 | 9 (0.28) | 21 |
| 11 | 5 | 9 | 14 (0.3) | 1 | 5 | 6 (0.11) | 20 |
| 12 | 10 | 11 | 21 (0.01) | 1 | 8 | 9 (0.04) | 30 |
| 13 | NA | 3 | 3 (0.36) | NA | 2 | 2 (0.24) | 5 |
| 14 | NA | 10 | 10 (0.27) | NA | 4 | 4 (0.17) | 14 |
| 15 | NA | 8 | 8 (0.01) | NA | 5 | 5 (0.19) | 13 |
| 16 | 3 | 3 | 6 (0.11) | 2 | 4 | 6 (0.07) | 12 |
| 17 | 4 | 8 | 12 (0.3) | 1 | 5 | 6 (0.22) | 18 |
| 18 | 4 | 0 | 4 (0.3) | 1 | 0 | 1 (0.44) | 5 |
| 19 | 8 | 18 | 26 (0.01) | 3 | 4 | 7 (0.37) | 33 |
| 20 | 1 | 8 | 9 (0.26) | 2 | 3 | 5 (0.41) | 14 |
| 21 | NA | 2 | 2 (0.23) | NA | 4 | 4 (0.05) | 6 |
| 22 | NA | 8 | 8 (0.45) | NA | 2 | 2 (0.2) | 10 |
| X | 2 | 1 | 3 (0.07) | 4 | 5 | 9 (0.08) | 12 |
| Y | 0 | 0 | NA | NA | 0 | NA | 0 |
A total of 568 transcripts were up‐ or down‐regulated with statistical significance in which 395 known gene symbols were identified. In order to investigate and find statistically significant hot spots, the location of altered genes was compared with the list of all genes that are transcribed in both tumor and normal samples. The analysis was performed using Onto‐Express online software (http://vortex.cs.wayne.edu/index.htm).
Values in parentheses are P values.