Table 1.

The receptor systems and accessory signaling molecules used by the three IFN types for signal transduction

IFN type	Interferons	Receptor	Signaling molecules
Type I	α (13 types), β, δ, ε, κ, τ, ω, ζ	IFNAR1, IFNAR2	JAK1, Tyk2 STAT‐1, ‐2, ‐3, ‐4, ‐5 MAPK, PI3K, Akt, NFκB p53, PRMT1
Type II	γ	IFNGR1, IFNGR2	JAK1, JAK2 STAT‐1,‐2, ‐3, ‐5 MAPK, PI3K, Akt, NFκB
Type III	λ	IFNLR1, IL10RB	JAK1, Tyk2 STAT‐1, ‐2, ‐3, ‐4, ‐5 MAPK, PI3K, Akt

Abbreviations: IFN, interferon; IL, interleukin.