Table 2.
Cell type and tissue‐specific presentation of IFN receptors
| Cell/tissue | Interferon receptor | |||||
|---|---|---|---|---|---|---|
| Type I | Type II | Type III | ||||
| IFNAR1 | IFNAR2 | IFNGR1 | IFNGR2 | IFNLR1 | IL10R | |
| T cells | ||||||
| CD4+ | + 1 | + 1 | + 3 | + 3 | − 7 | + 8 |
| CD8+ | + 2 | + 2 | + 4 | − 4 | − 7 | + 8 |
| Th1 | + 5 , 6 | − 5 , 6 | ||||
| Th2 | + 5 , 6 | + 5 , 6 | ||||
| B cells | + 1 , 9 | + 1 , 9 | + 10 | + 10 | − 7 | + 11 |
| Astrocytes | +NS 12 | +NS 13 | − | + 13 | ||
| NK cells | + 14 | + 14 | + 15 | + 15 | − | ND |
| Epithelial cells | + 16 | + 16 | +/− 10 | +/− 10 | + 7 , 17 | + 18 |
| Endothelial cells | +NS 19 | + 20 | + 20 | − 17 | + 21 | |
| Plasmacytoid DCs | + 22 | + 22 | + 3 | + 3 | + 7 | + 23 |
| PBMCs | + 24 | + 24 | + 25 | + 25 | ND | + 26 |
| Tumor/cancer cells | + 27 , 28 , 29 | + 27 , 28 , 29 | + 15 | + 15 | ND | ND |
| Macrophages | + 30 | + 30 | + 10 | + 10 | − 7 | + 31 |
| Hepatocytes | + 32 | + 32 | +Low 10 | +Low 10 | + 33 | + 34 |
| Platelets | − 35 | − 35 | + 15 | + 15 | ND | + 36 |
| Fibroblasts | + 37 | ND | + 15 | + 15 | − 7 | + 38 |
| Phagocytes | ND | ND | + 15 | + 15 | ND | + |
| Eosinophils | + 39 | + 39 | + 40 | ND | + 41 | + 8 |
| Myeloid cells | + 42 | ND | ND | ND | ND | + 26 |
| Serum | ND | +(Soluble) 11 | ND | ND | ND | ND |
| Erythrocytes | ND | ND | − 15 | − 15 | ND | + 43 |
| Keratinocytes | + 44 | + 44 | + 45 | + 45 | + 7 | + 46 |
| Mouse oocytes | ND | ND | + 47 | + 47 | ND | ND |
| Megakaryocytes | + 35 | + 35 | ND | ND | ND | ND |
| Kidney | ND | ND | ND | ND | + 17 , 48 | + 49 |
| Brain | +/− 42 , a | Low a | Low a | +/− a | +/− 17 , a | Low 50 |
| CNS | + 42 | ND | + 51 | + 51 | ND | + 13 |
| Liver | + 52 | + 52 | Low 10 | Low 10 | − 17 | + 49 |
| Lung | + 53 | + 53 | ND | ND | + 17 , 48 | + 49 |
| Gastrointestinal tract | + 54 | + 54 | + 10 | + 10 | + 48 | + 49 |
| Preimplantation embryos | ND | ND | + 47 | + 47 | ND | ND |
Abbreviations: CNS, central nervous system; DCs, dendritic cells; IFN, interferon; IL, interleukin PBMCs, peripheral blood mononuclear cells.
‘+’ represents cell types experimentally demonstrated to present IFN receptors on the surface or for which this is inferred by responsiveness to the IFN type given. ‘−’ represents cell types that have been demonstrated to be negative. ‘ND’ represents cell types or tissues in which the presence of the relevant receptor components have not been demonstrated or are not reported as being found. ‘NS’ is used to demonstrate that the identity of the receptors were not specified.
References cited in the table are availalbe in Supplementary Information.
data for receptor distribution in the brain was also taken from the Allen Brain Atlas at http://www.brain-map.org.