Table 3.

Mechanisms of regulation of cell surface levels of the receptors for type I, type II and type III IFNs

Interferon	Mechanism of regulation	Reference
Type I	Tyk2 association	55
	SOCS1	56
	Ubiquitination	57 , 58
	Endocytosis	55
	Lysosomal degradation	59
	LPS	60
	Bcr‐abl	61
	P38	62
	VEGF	63
Type II	TCR activation	64
	Endocytosis	65
	Differential basal expression	5 , 6 , 15
	Bacterial/protozoan infection	66 , 67 , 68 , 69 , 70
	Other cytokines	69 , 70 , 71
Type III	No information available

Abbreviations: IFN, interferon; LPS, lipopolysaccharide; SOCS1, suppressor of cytokine signaling 1; TCR, T‐cell receptor; VEGF, vascular endothelial growth factor.

References cited in the table are availalbe in Supplementary Information.