Table 2.
Viral infections of mice deficient for MyD88, IRAK‐4, or UNC‐93B components
| Component | Infection | Phenotype | References | ||
|---|---|---|---|---|---|
| Survival rate | Viral load | Other | |||
| MyD88 | Herpes simplex virus 1 (HSV‐1) | ↓ | ↑ in the brain | (77) | |
| NT | No difference | (78) | |||
| Vesicular stomatitis virus (VSV) | ↓ | ↑ in the brain | ↓ IFN‐α production | (47, 82) | |
| No difference | NT | (82) | |||
| Mouse cytomegalovirus (MCMV) | ↓ | ↑ in the spleen | ↓ IFN‐α/β production and NK cell activation | (5, 79) | |
| Lymphocytic choriomenigitis virus (LCMV) | NT | ↑ | ↓ CD8+ T‐cell response | (80) | |
| Encephalomyocarditis virus (EMCV) | ↓ | NT | ↓ IFN‐α in the serum | (81) | |
| Respiratory virus (RSV) | NT | NT | ↓ eosinophils and mucus production in the pulmonary environment | (83) | |
| Coxsackievirus B3 (CVB3) | ↑ | ↓ in the heart | ↓ inflammatory cytokines, ↑ IFN‐β expression in the heart | (84) | |
| IRAK‐4 | Lymphocytic choriomenigitis virus (LCMV) | NT | NT | ↓ IFN‐γ production | (71) |
| UNC‐93B | Mouse cytomegalovirus (MCMV) | ↓ | ↑ in the spleen | ↓ Production of IFN‐α/β and other cytokines | (92) |
↑ increased; ↓ decreased; NT not tested.