Table 3.
Viral serological data for patients deficient for IRAK‐4, UNC‐93B, or TLR3
Genetic defect | Infection | Positive serological tests (with vaccines) | References | |||
---|---|---|---|---|---|---|
dsDNA | ssDNA | ss−RNA | ss+RNA | |||
IRAK‐4 (nine patients) | Gram‐positive bacteria | HSV‐1, EBV, CMV VZV, HHV‐6 Metapneumovirus | Parvovirus B19 | Mumps, measles RSV | CoxB1, rubella | (67, 85, 86) |
UNC‐93B (two patients) | HSE | HSV‐1, EBV, CMV VZV, HHV‐6 | Parvovirus B19 | Mumps, measles RSV Influenza A and B parainflenzae 1 | CoxB1, rubella poliovirus | (68) |
TLR3 (two patients) | HSE | HSV‐1, EBV, CMV VZV, HHV‐6 HBV | Mumps, measles | CoxB1, rubella | (69) |
Note: Positive serological results in at least one patient are indicated.
HSE, herpes simplex encephalitis; HSV‐1, herpes simplex virus‐1; VZV, varicella zoster virus; RSV, respiratory syncytial virus; EBV, Epstein–Barr virus; HHV‐6, human herpes virus‐6; CoxB1, coxsackievirus B1; CMV, cytomegalovirus; HBV, hepatitis B virus.