Table 2.
The pNfH concentration in different MND motor and cognitive phenotypes
| Case number | pNfH (pg/ml) | |
|---|---|---|
| Motor phenotype | ||
| Classic | 82/219 (37.4%) | 226.2 (89.6–449.5) |
| Bulbar | 31/219 (14.2%) | 248.2 (153.0–651.6) |
| Pyramidal | 31/219 (14.2%) | 254.3 (108.4–407.6) |
| Flail arm | 10/219 (4.6%) | 70.6 (23.5–120.4) |
| Flail leg | 30/219 (13.7%) | 153.4 (23.5–351.1) |
| Respiratory | 2/219 (0.9%) | 85.8 (–) |
| PLMN | 23/219 (10.5%) | 40.0 (23.5–112.2) |
| PUMN | 10/219 (4.6%) | 32.7 (23.5–127.6) |
| Cognitive phenotype | ||
| ALS motor | 52/118 (44.1%) | 131.6 (23.5–318.7) |
| ALS-FTD | 21/118 (17.8%) | 184.1 (90.4–523.7) |
| ALS-bi | 11/118 (9.3%) | 339.2 (74.2–688.0) |
| ALS-ci | 24/118 (20.3%) | 202.3 (66.9–435.3) |
| ALS-cbi | 10/118 (8.5%) | 292.3 (23.5–586.8) |
Median values and interquartile range (IQR) are given
pNfH phosphorylated heavy chain, PLMN pure lower motor neuron, PUMN pure upper motor neuron, ALS-FTD frontotemporal dementia (FTD), ALS-bi behavioral impairment, ALS-ci cognitive impairment, ALS-cbi combined cognitive and behavioral impairment