Fig. 1.

Atrophy-related E3 ubiquitin ligases are not induced in AR113Q skeletal muscle. a Relative mRNA expression of FBXO32/Atrogin-1, MuRF1, and MuSA1 in WT control (ctrl) and denervated (den) mouse gastrocnemius 3 days following sciatic nerve transection (n = 3/group). b Relative mRNA expression of FBXO32/Atrogin-1, MuRF1, and MuSA1 in AR113Q control (ctrl) and denervated (den) mouse gastrocnemius 3 days following sciatic nerve transection (n = 3/group). c–e Relative mRNA expression of (c) MuRF1, (d) FBXO32/Atrogin-1, (e) MuSA1 in WT or AR113Q mice in quadriceps (Quad) at 14, 26 and 52 weeks (left, n = 6/group) and in LABC at 14 weeks (right, n = 3/group). Data are shown as mean ± SEM. ns not significant (p > 0.05), *p < 0.05; **p < 0.01; ***p < 0.001 by unpaired t test (quadriceps) or by one-way ANOVA with Tukey’s (LABC)