Fig. 5.

AR113Q muscle shows hormone- and Q tract length-dependent MEF2 impairment and sequestration. a–c Relative mRNA expression of MEF2 targets was measured in the LABC of a WT, AR21Q, and AR113Q mice at 14 weeks of age. (n = 3/group), b WT mice at 14 weeks of age compared to WT mice castrated at 6 weeks and allowed to age to 14 weeks (WT C). (n = 3–5/group), and c AR113Q mice at 14 weeks of age compared to AR113Q mice castrated at 6 weeks and allowed to age to 14 weeks (AR113Q C) (n = 3–5/group) d Co-localization of p62 and MEF2A/C in LABC of WT and AR113Q mice at 14 weeks of age, quantified at right (n = 3 mice/group). Data are shown as mean ± SEM. Scale bar = 10 µm. *p < 0.05; **p < 0.01; ***p < 0.001, ****p < 0.0001 by unpaired t test (a, b, d) or one-way ANOVA with Tukey’s (c)