Table 1A.

Population baseline and therapeutic drug monitoring data.

Characteristics	n = 20
Sex ratio M/F	14/6
Age (years old)	65 [62–72]
Total body weight (kg)	84 [75–95]
Ideal body weight (kg)	66 [62–71]
Body mass index (kg/m2)	28.5 [26–31]
Comorbidities
Hypertension	12 (60)
Diabetes	8 (40)
Ischemic heart disease	3 (15)
COPD	4 (20)
Obstructive sleep apnoea	6 (30)
Chronic kidney diseasea	1 (5)
ICU data
SOFA scored at admission	7 [5–8]
SAPS IIe	37 [33–48]
PaO2/FiO2 at admission	97 [81–127]
Albumin level (g/L)	23.4 [21.1–27.2]
Acute renal failure KDIGO 1	5 (25%)
Measured renal clearance (mL/min)b	98 [68–120]
Fluid balance (mL)c	−465 [−823; +165]

Data are presented as: n (%), median [Q1–Q3].

^aChronic kidney disease was defined as a creatinine renal clearance < 60 mL/min/m².

^bRenal clearance was measured using the (Urine_Creatinine × volume)/P_Creatinine formula.

^cFluid balance was calculated the day of the dosage of β-lactam concentration.

^dSequential Organ Failure Assessment Score.

^eSimplified Acute Physiology Score.