Table 1.

Clinical laboratory results.

Variables	Reference range	HD1	HD3	HD6	HD9	HD12	HD15
		Illness day 11
Complete blood cell count
White blood cells (/μl)	3300–8600	5300	6500	7400	11,600	104,000	6300
Segment neutrophil (%)	37–80	78.6	84.4	78.8	76.7	78.8	69.4
Lymphocyte (%)	11–50	11.5	9.8	12.7	14.4	10.8	14.9
Hemoglobin (g/dl)	13.7–16.8	14.1	12.3	11.4	12.4	11.4	8.9
Platelets (×104/μl)	13.0–35.0	21.9	18.7	17.6	17.1	14.7	23.7
Blood chemistry
Total protein (g/dl)	6.6–8.1	5.8	–	–	–	–	–
Albumin (g/dl)	4.1–5.1	2.8	2.1	1.5	2	2.4	2
Urea nitrogen (mg/dl)	8.0–20.0	15.9	13.5	22.8	21.8	33.6	15.9
Creatinine (mg/dl)	0.65–1.07	0.82	0.55	0.65	0.71	0.62	0.49
Total bilirubin (mg/dl)	0.40–1.50	0.26	0.73	0.55	0.37	0.62	0.36
Aspartate aminotransferase (U/l)	13–30	50	65	48	28	22	15
Alanine aminotransferase (U/l)	10–42	48	66	56	30	20	16
Alkaline phosphatase (U/l)	106–322	149	–	238	242	–	–
Lactate dehydrogenase (U/l)	124–222	598	571	410	452	438	221
Creatinine kinase (U/l)	59–248	38	73	18	–	59	–
Sodium (mmol/l)	138–145	134	145	147	142	138	139
Potassium (mmol/l)	3.6–4.8	3.3	3.9	3.7	4	4.3	3.7
Glucose (mg/dl)	73–109	178	157	147	157	213	97
C-reactive protein (mg/dl)	0.00–0.14	20.28	26.24	16.77	2.58	13.82	6.78
Procalcitonin (ng/ml)	0.00–0.05	0.14	–	–	–	–	–
Blood coagulation
Prothrombin time (%)	75–120	110	94.5	99.2	104.2	97.6	97.4
Activated partial thrombin time (sec)	24.0–39.0	35.4	41.5	64.6	62.8	60.6	35.1
Fibrinogen (mg/dl)	200–400	536	629	–	–	423	–
D-dimer (μg/ml)	＜1.0	1.5	2.3	3.8	3.3	13.4	–

Abbreviations: HD, Hospital day.