Skip to main content
. Author manuscript; available in PMC: 2020 Sep 27.
Published in final edited form as: J Nat Prod. 2020 Mar 11;83(3):593–600. doi: 10.1021/acs.jnatprod.9b00989

Figure 5.

Figure 5.

Substrate specificity of AnATPKS A domain. (A) Substrate profiling of the adenylation domain. The A domain exhibits relaxed substrate specificity towards substituted phenylalanine analogs. (B) Precursor feeding led to biosynthesis of substituted pyrophen analogues. Feeding of different phenylalanine analogues to A. nidulans transformants led to production of substituted pyrophen analogues (6–11), which were isolated and structurally characterized. Note that 11 may be racemic as suggested by the optical rotation data.