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. 2020 Apr 14;14:1455–1468. doi: 10.2147/DDDT.S243420

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© 2020 Liao et al.

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Isoliquiritigenin reduced the inflammatory response induced by LPS in BMDM. (A–D) ISL can reduce the mRNA expression of inflammatory cytokines in LPS-induced BMDM, including IL-1β, IL-6, TNF-α and MCP-1. **P<0.01, vs LPS group. ***P<0.001, vs LPS group. ****P<0.0001, vs LPS group; (E, F) ISL reduced the secretion of IL-1β and IL-6 in supernatant of LPS-stimulated BMDM. **P<0.01, vs LPS group; (G) immunofluorescence results showed that ISL inhibited the protein level of IL-1β and IL-6 in LPS-stimulated BMDM.