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. 2020 Apr 14;14:1455–1468. doi: 10.2147/DDDT.S243420

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© 2020 Liao et al.

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Isoliquiritigenin suppressed inflammation through Mincle-dependent mechanism in BMDM cells. (A) In the Mincle recovery experiment, we used TDB to upregulate Mincle in ISL-treated inflammatory BMDM. The results showed that the protein level of Mincle (B), iNOS (C), phosphorylated Syk (D) and phosphorylated NF-kappa B (E) were significantly increased in ISL-treated inflammatory BMDM, suggesting ISL inhibits inflammation by suppressing Mincle; Overexpression of Mincle by administration of TDB, upregulated the expression (F–I) and secretion (J–L) of IL-1β, IL-6 and TNF-α and MCP-1 in ISL-treated inflammatory BMDM.

Notes: *P<0.05, vs LPS group. **P<0.01, vs LPS group. ***P<0.001, vs LPS group. ^#P<0.05, vs LPS+ISL 40μM-treated group. ^##P<0.01, vs LPS+ISL 40μM-treated group. ^###P<0.001, vs LPS+ISL 40μM-treated group.