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. 2020 Apr 14;13:3105–3115. doi: 10.2147/OTT.S234819

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© 2020 Xie et al.

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Downregulation of TUG1 inhibited CXCR4 expression. (A) The mRNA levels of CXCR4 affected by TUG1 downregulation. The effects of TUG1 downregulation on the protein levels of CXCR4 were detected by using Western blotting (B) and immunofluorescence method (C). (D) Predicted miRNAs that had capacity of binding with TUG1 and CXCR4. (E) Predicted consequential pairing of TUG1 and two miRNAs. (F) Inhibiting TUG1 increased miR-335-5p, but not miR-9-3p expression. (G) Predicted consequential pairing of miR-335-5p and CXCR4. (H) Exogenous miR-335-5p decreased CXCR4 expression at both the mRNA and protein levels. *P<0.05, **P<0.01, ***P<0.001.

Abbreviation: ns, non-significant.