Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Apr 7;31(1):107490. doi: 10.1016/j.celrep.2020.03.054

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Progressive Reduction of AER-Fgf8 Expression Correlates with the Loss of Digit I and the Reduced Length of Digits II and V in Pig Limb Buds

(A and B) Comparative analysis of Fgf8 expression during handplate (A) and digit ray development (B) in mouse and pig limb buds. Black arrowheads in (A) point to the posterior-proximal limit of Fgf8 expression. Right panels in (B) are close-ups of the anterior margins of the limb buds shown in the left panels.

(C) Mouse (E13.25) and pig forelimbs (D30) stained with Alcian blue to reveal the cartilage condensation patterns that prefigure the definitive digit rays.

Asterisks indicate vestigial digit I condensation. Scale bars, 0.25 mm. n = 2 per stage for all pig ISH probes and skeletal stainings; n = 3 per stage for all mouse ISH probes and skeletal stainings.