Table 3.

Genetic Associations of T2DM With TB-Related SNPs in the UK Biobank (13 976 T2DM Cases, 310 267 Controls)

CHROM	POS	SNP ID	Allelesa	Freqb	Model 1c		Model 2d
					OR (95% CI)	P Value	OR (95% CI)	P Value
6	31628397	rs148844907	T/A	0.01	0.974 (0.875–1.084)	.633	0.977 (0.877–1.088)	.67
6	32390578	rs3135359	T/C	0.73	1.061 (1.026–1.096)	.001	1.060 (1.025–1.096)	.001
6	32433276	rs2894257	G/C	0.51	1.111 (1.077–1.145)	1.42×10–11	1.106 (1.073–1.140)	1.14×10-10
8	131296767	rs4733781	C/A	0.69	1.030 (1.003–1.058)	.026	1.031 (1.004–1.058)	.024
11	32364187	rs2057178	A/G	0.84	0.988 (0.956–1.022)	.488	0.986 (0.954–1.020)	.427
18	20190795	rs4331426	G/A	0.97	0.973 (0.909–1.041)	.421	0.970 (0.906–1.037)	.371

Abbreviations: CHROM, chromosome number; CI, confidence interval; Freq, frequency of effect allele; OR, odds ratio; POS, base pair position (GRCh37/hg19); SNP, single nucleotide polymorphism.

^aThe 2 alleles represent reference/effect alleles.

^bFreq: frequency of effect allele.

^cModel 1: basic adjusted model with age, sex, body mass index, principal components 1–10.

^dModel 2: full adjusted model with age, sex, body mass index, smoking, alcohol, principal components 1–10.