Figure 2. Diminished transcriptional response to isoniazid exposure in NRP2.
Gene expression profiles of 100 genes (71 induced, 29 repressed) significantly differentially expressed after INH treatment in aerobic conditions are plotted (±INH) alongside the expression pattern of these genes in NRP1 and NRP2. The expression ratios are presented as fold-change relative to drug-free growth state controls.
INH: Isoniazid; NRP: Nonreplicating persistence.