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. Author manuscript; available in PMC: 2020 Apr 18.
Published in final edited form as: Future Med Chem. 2010 Aug 1;2(8):1371–1383. doi: 10.4155/FMC.10.219

Figure 3. The absence of a transcriptional response to isoniazid in NRP2 bacilli, verified by quantitative RT-PCR with a panel of genes chosen to exemplify the isoniazid transcriptional signature and the physiological status of bacilli.

Figure 3

Expression ratios, marked in fold-change, were calculated relative to sigA and drug-free growth controls using the ΔΔCt method. Standard deviations from triplicate samples are marked. Red–pink coloring highlights genes selected to assay INH mechanism of action; blue coloring indicates genes chosen to illustrate the metabolic and respiratory state of bacilli.

INH: Isoniazid; NRP: Nonreplicating persistence.

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