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. Author manuscript; available in PMC: 2020 Apr 18.
Published in final edited form as: Future Med Chem. 2010 Aug 1;2(8):1371–1383. doi: 10.4155/FMC.10.219

Figure 6. Expression pattern of isoniazid-responsive genes in log-phase and NRP2 bacilli ± isoniazid relative to drug-free log-phase bacilli.

Figure 6

A total of 100 genes, identified as significantly differentially regulated after isoniazid (INH) exposure in AG conditions, were clustered alongside the NRP2 transcriptional profiles. (A & B) show genes induced or repressed after INH exposure and transition to NRP2 compared with untreated log-phase bacilli. Genes are displayed as rows and growth conditions ± INH as columns. Red: induction; blue: repression relative to log-phase drug-free control.

†Genes significantly differentially expressed in both drug-free NRP2 and INH-treated AG bacilli compared with untreated log-phase bacilli.

AG: Aerobic; NRP: Nonreplicating persistence.

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