Table 1. MCC Cases Tested for MCV T antigen Expression.
| Case # | Age | Sex | Site | IHC |
Treatment | Outcome | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CD56 | CK20 | Chromogranin | CK7 | Synaptophysin | Others | MCVLT (CM2B4) |
MCVLT (Ab3) |
MCVLT (PCR) |
||||||
| 1 | 59 | M | Groin | + | + | + | – | – | HMWCK- | – | – | + | NK | Metastais (LN) |
| 2 | 37 | M | Thigh | + | + | + | + | c-KIT+, MIC2- | + | + | + | Rx, Rx-R0 resection | NK | |
| 3* | 37 | F | Wrist | + | + | – | MIB1-100- | – | – | + | Excision, R0 resection | FOD(21mo) | ||
| 4 | 67 | M | AxillaLN | + | + | – | + | CK+, EMA+, AE1A3+ | + | + | + | Excision, CT(Etoposide, Carboplatin) | FOD(16mo) | |
| 5 | 74 | M | Leg | + | + | CK- | – | – | + | NK | NK | |||
| 6 | 60 | F | Scalp | + | + | + | – | + | CK+,NSE + EMA+,MIB1-80- | – | – | NT | NK | NK |
| 7 | 57 | F | Nose | + | + | EMA+,CK- | + | + | NT | Excision | NK | |||
| 8 | 64 | M | Knee | + | + | EMA+, CK+,S100P- | – | – | NT | Excision | NK | |||
| 9 | 72 | M | Neck | + | + | AE1/AE3+,c-KIT+ | – | – | + | Excision | NK | |||
| 10 | 59 | M | Thumb | + | + | – | + | c-KIT+ | – | NT | NT | Amputation & CT (Paclitaxel, Carboplatin, Etoposide, Imatinib) | Metastasis (Scalp) | |
| 11 | 66 | M | Thigh | + | + | + | – | + | HMB45-,S100P-,AE1/AE3+ | – | – | + | Supportive Care | Metastasis (LN & Lung) |
| 12 | 74 | F | Knee | + | + | S100P-, GFAP-,AE1/AE3+, EMA-,BCl2+ | – | + | – | NK | NK | |||
| 13 | 62 | F | Arm | + | AE1/AE3+, MIC-2+, Desmin-,Tdt- | – | + | + | NK | NK | ||||
| 14 | 62 | F | Thigh | + | + | + | MIC2+, AE1/AE3+, Desmin-, MyoD1-, Myogenin- | – | – | – | NK | NK | ||
| 15 | 60 | F | Neck (Submadibular) | + | + | + | + | EMA+ | – | – | NT | NK | NK | |
| 16 | 50 | M | Chest wall | + | – | + | AE1/AE3+, MIC2+, Fli1+,Desmin- | – | – | – | NK | NK | ||
| 17 | 42 | M | Upper Arm | + | + | + | AE1/AE3+, MIC2+, Fli1+,Desmin-, S100P- | + | + | – | NK | NK | ||
| 18 | 49 | M | Inguinal and Gluteal | + | + | MIC2+,Desmin- | + | NT | NT | CT | Metastais (LN) | |||
Abbreviations: F-female, M-Male,+ -positive, − -negative,NT-Not tested, HMWCK-High molecular weight cytokeratin, EMA-Epithelial membrane antigen, CK- Cytokeratin, AE1/AE3- Pan- Cytokeratin, NSE- Neuron specific enolase, MIB1-Mind Bomb1, S100P–S100 calcium-binding protein P, HMB45-Human melanoma Black, GFAP-Glial fibrillary acid protein, MIC2-Cluster of differentiation 99 (CD99), Tdt-Terminal deoxynucleotidyl transferase, Fli1- Friend Leukemia Integration, * -MCC with coexisting Bowen disease., NK-not known, CT-chemotherapy, FOD-free-of-disease, LN-Lymph Node.