Table 1:

Linear regression analyses of all the genes in EGFR receptor family and its ligands, and, chronic characteristic pain intensity (CPI) in OPPERA cohort, corrected for age, gender and the first three principal components. Only significant results (FDR ≤ 5%) are presented.

Gene	SNP	Ref	Min	Base pair location	β	P-val	FDR
EREG	rs10518126	G	A	75243119	−11.09	0.0000078	0.00944**
EREG	rs57839099	G	A	75243813	−11.09	0.0000078	0.00944**
EREG	rs200889776	G	A	75240770	−10.41	0.00002	0.011*
EREG	rs57933408	G	A	75243828	−10.51	0.00002	0.011*
EREG	rs201835071	G	A	75237587	−9.99	0.00003	0.011*
EREG	rs72859363	A	G	75246112	−10.24	0.00003	0.011*
EREG	rs6836436	A	C	75230930	−8.84	0.00013	0.041*

SNP: single nucleotide polymorphism (rs ID); Ref: reference allele; Min: minor allele; β: slope of least-squares line; FDR: false discovery rate;

^‘**’:FDR ≤ 0.01

^‘*’:0.05