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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Pain. 2020 May;161(5):1052–1064. doi: 10.1097/j.pain.0000000000001792

Table 3:

Haplotype frequencies of EREG as estimated through Expectation – Maximization (E-M) Algorithm:

Haplotype* OPPERA (n = 2,755) UK biobank (n = 473,879)
H1 67.33 % 74.65 %
H2 20.39 % 19.91 %
H3 7.61 % 2.77 %
Log-likelihood −4400.5 −563884.5
lr stat for no LDϮ 3404.9 588766.6
p-value 8.63 × 10−08 4.99 × 10−23
*

haplotypes with frequencies > 5 % in OPPERA and > 2 % in UK biobank;

Ϯ

likelihood ratio test statistic contrasting the log-likelihood for the estimated haplotype frequencies versus the log-likelihood under the null assuming that the alleles from all the three loci are in linkage equilibrium.