Table 1.

Study design of [¹⁴C]HMB in Harlan Sprague Dawley rats and B6C3F1/N mice.

Species	Route	Sex	Dose (mg/kg)	Study Duration (h)	End Point
Rat	Oral Gavage	male	10, 100, 500	24a, 72	Dose response
		male	100	2, 72	Tissue Distribution
		female	100	72	Sex Difference
		male/female	10	24	Toxicokinetic Study
	Dermal	male	10b, c, d, e,f	72	Route Difference
		male	0.1b	72	Tissue Distribution
		female	1c, 15c	72	Sex difference
	IV	male	10	72	Route Difference
		male	10	6	Excretion in Bile
		male/female	10	24	Toxicokinetic Study
Mouse	Oral Gavage	male	100, 500	72	Dose Response
		female	100	72	Sex Difference
	Dermal	male	1f, 10f	72	Dose Response
		male	10c, f, g	72	Route Difference
		female	10c, f	72	Sex difference
	IV	male	10	72	Route Difference

^aDisposition of radioactivity 24 h of following oral gavage administration of 10 mg/kg [¹⁴C]HMB in male HSD rats

^bLight Paraffin Oil,

^cLotion,

^dCoconut oil,

^e1:1 Ethanol:Coconut Oil,

^fEthanol,

^gAcetone