Table 3.
Distribution and cumulative excretion of radioactivity up to 72 h following a single dermal application of [14C]HMB to male and female Harlan Sprague-Dawley rats
| Sample | Cumulative percent of dose recovereda | |||||||
|---|---|---|---|---|---|---|---|---|
| Male, Paraffin Oil 10 mg/kg |
Male, Lotion 10 mg/kg |
Male, Coconut Oil 10 mg/kg |
Male, Ethanol:Coconut Oil 10 mg/kg |
Male, Ethanol 10 mg/kg |
Male, Paraffin Oil 0.1 mg/kg |
Male, Ethanol 1 mg/kg |
Female, Lotion 15 mg/kg |
|
| Urine (cage rinse) |
36.1±4.5 (12.0±3.3) |
11.9±5.0 (5.96±2.44) |
26.4±2.1 (5.66±2.14) |
28.7±3.5 (8.38±1.79) |
24.5±3.9 (9.51±3.18) |
28.7±4.9 (8.08±2.31) |
24.1±2.6 (6.93±1.86) |
11.4±3.6 (4.70±1.42) |
| Feces | 21.1±3.4 | 21.7±26.9 | 15.3±1.9 | 21.8±5.5 | 21.8±2.8 | 21.1±2.1 | 21.3±4.4 | 8.84±1.21 |
| GI Content | 1.56±0.66 | 2.45±0.61 | 2.38±0.95 | 2.50±0.65 | 1.24±0.32 | 2.35±0.68 | 0.73±0.17 | 2.00±0.48 |
| Tissues | 6.02±2.22 | 2.79±0.72 | 8.31±6.83 | 8.18±2.83 | 7.39±2.09 | 9.74±8.74 | 4.16±3.40 | 1.64±0.69 |
| Total absorbed doseb | 79.8±6.9 | 45.8±35.5 | 64.3±8.2 | 72.5±6.0 | 67.8±3.2 | 72.5±8.5 | 53.4±4.7 | 28.9±4.10 |
| Total dose site skin | 0.11±0.08 | 1.58±0.72 | 0.43±0.23 | 0.22±0.09 | 0.28±0.145 | 0.37±0.14 | 54.3±4.7 | 2.68±2.62 |
| Total unabsorbed dosec | 1.52±0.42 | 51.7±23.0 | 10.7±2.9 | 4.41±1.81 | 16.2±4.5 | 6.66±1.72 | 22.4±2.8 | 56.0±7.20 |
| Total dose recovered | 79.8±7.0 | 99.1±13.3 | 72.5±5.3 | 76.9±6.7 | 82.7±5.5 | 79.5±7.0 | 76.3±5.4 | 87.6±2.70 |
a
All Values expressed as mean (± SD) for N=5,
b
Total absorbed dose is the total administered dose recovered in excreta, GI content, carcass, and tissues.
c
Total unabsorbed dose is the total administered dose recovered in dose site wipes, tape/glue, and applicator.