Table 4.

Distribution and cumulative excretion of radioactivity up to 72 h following a single oral and IV administration of [¹⁴C]HMB to male and female B6C3F1/N mice

Sample	Cumulative percent of dose recovereda
	Oral Gavage			IV
	Male 100 mg/kg	Male 500 mg/kg	Female 100 mg/kg	Male 10 mg/kg
Urineb (cage rinse)	17.5±14.0 (23.9±10.6)	18.2±22.8 (21.5±8.7)	4.24±4.35 (29.7±7.0)	4.13±6.45 (12.2±4.4)
Fecesb	38.7±2.8	24.3±8.0	23.9±8.8	29.2±6.9
Volatile organicsc	0.83±0.20	-	0.73±0.07	-
CO2c	5.51±0.87	-	15.6±21.3	-
GI contentb	0.06±0.05	0.05±0.02	0.06±0.04	0.11±0.04
Foodb	-	-	-	11.5±7.4
Carcassb	1.53±0.20	0.70±0.48	0.12±0.16	0.20±0.10
Tailb	-	-	-	1.12±0.59
Tissuesb	0.25±0.05	0.55±0.42	0.16±0.04	0.28±0.07
Total recovered	88.9±21.5	69.0±15.2	76.0±28.6	58.8±10.7

^aAll Values expressed as mean (± SD) for N=5 for oral gavage and N=3 for IV,

^b72 h,

^c24 h