Table 5.

Distribution and cumulative excretion of radioactivity up to 72 h following a single dermal application of [¹⁴C]HMB to male and female B6C3F1/N mice

Sample	Cumulative percent of dose recovereda
	Male, Lotion 10 mg/kg	Female, Lotion 10 mg/kg	Male, Ethanol 1 mg/kg	Male, Ethanol 10 mg/kg	Female, Ethanol 10 mg/kg	Male, Acetone 10 mg/kg
Urine (cage rinse)	6.40±4.77 (7.00±1.75)	3.62±2.46 (12.5±3.4)	3.01±5.48 (11.8±4.1)	4.77±4.67 (15.8±3.4)	5.29±7.78 (15.2±2.4)	2.63±3.01 (16.2±4.61)
Feces	20.9±6.8	26.3±9.9	20.5±4.5	32.4±4.9	39.4±10.2	29.5±4.1
GI Content	0.58±0.15	0.71±0.11	0.30±0.15	0.72±0.19	0.34±0.07	0.57±0.21
Tissues	0.76±0.10	1.18±0.25	0.67±0.07	0.78±0.19	0.66±0.10	3.31±2.33
Total absorbed doseb	36.8±8.2	46.2±7.3	41.4±3.7	63.6±7.5	68.6±8.6	57.2±2.8
Total dose site skin	1.86±0.95	0.66±0.60	1.39±0.28	0.69±0.16	1.27±0.44	1.10±0.43
Total unabsorbed dosec	36.6±4.50	40.7±5.0	26.9±7.1	18.9±4.4	15.3±5.2	19.5±8.2
Total dose recovered	75.3±10.9	87.5±8.3	69.7±6.3	83.2±6.0	85.2±7.6	77.8±9.0

^aAll Values expressed as mean (± SD) for N=5,

^bTotal absorbed dose is the total administered dose recovered in excreta, GI content, carcass, and tissues.

^cTotal unabsorbed dose is the total administered dose recovered in dose site wipes, tape/glue, and applicator