Figure 5:

Cartoon of a joint sequence and chromatin continuum for induced TF binding outcomes. Some sites with strongly favorable sequence features (e.g. high affinity cognate motif instances, or multiple motif copies) might be bound regardless of prior chromatin status. Pioneered sites have low prior chromatin favorability but high sequence favorability. Sites that are opportunistically bound in cell type-specific patterns may have high prior chromatin favorability (e.g. highly accessible DNA, binding of cooperative TFs), which compensates for lower sequence favorability.