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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Biol Psychiatry. 2020 Jan 7;87(9):819–828. doi: 10.1016/j.biopsych.2019.12.021

Figure 4. Survival estimates of progression to Aβ-positivity based on baseline cognitive performance.

Figure 4.

Cox proportional hazard models were run using continuous measures of baseline performance. For display purposes, scores were grouped based on a median split and adjusted survival curves are shown for better (upper half) and worse (lower half) performance on baseline cognitive measures. Results from 4 models are presented: A) ADNI Memory composite (ADNI_MEM) + covariates; B) the Preclinical Alzheimer Cognitive Composite (PACC) + covariates; C) ADNI_MEM + covariates + baseline CSF Aβ and p-tau; D) PACC + covariates + baseline CSF Aβ and p-tau. CSF Aβ and P-tau were entered as continuous variables. Covariates include: APOE-ε4+ status, age at baseline, and education. P-values of hazard ratios for cognitive measures are shown for each model.