Fig. 2.

P2Y2 receptors are coupled to G protein and activate the PLC pathway. The PLC leads to the formation of InsP3, which in turn leads to the release of intracellular Ca⁺². When the PLC is activated, it also causes the generation of DAG, which in turn is a PKC activator that promotes the inhibition of the Na⁺/K⁺ATPase activity. Besides, the P2Y2 receptor also activates the MAPK pathway. All these intracellular effects caused by the activation of P2Y2 are promoters of tumor progression