Fig. 6.

Pharmacokinetics of MRS2978 in the male Sprague-Dawley rat. MRS2978 could be classified as a low clearance compound. MRS2978 was administered in a vehicle of 10% DMSO: 90% aqueous hydroxypropyl-β-cyclodextrin (20%). The AUC (0-inf, ng.h/ml) for MRS2978 was 550 (0.5 mg/kg, i.v.), 644 (1 mg/kg, p.o.), 1870 (3 mg/kg, p.o.) and 8270 (10 mg/kg, p.o.)