Fig. 7.

Appearance of unmasked MRS2925 as a metabolite of MRS2978 in the male Sprague-Dawley rat. MRS2978 was administered as in Fig. 6. The AUC (0-last, ng.h/ml) for MRS2925 (dose of MRS2978) was 27 (0.5 mg/kg, i.v.), below the level of quantification (1 mg/kg, p.o.), 37 (3 mg/kg, p.o.) and 54 (10 mg/kg, p.o.)