Table 1.
Top 20 genes in spinal cords altered by JNJ-47965567. RNA from spinal cords from end stage SOD1G93A mice was analysed by NanoString to determine changes in gene expression in JNJ-47965567-treated mice relative to β-CD-treated mice (n = 6 mice per group)
| Gene | Log2 (fold change ± SEM) | Pa |
|---|---|---|
| Nqo1 | − 2.2 ± 0.3 | 0.000139 |
| Gga1 | − 2.0 ± 0.3 | 0.00030 |
| Cntn4 | − 1.7 ± 0.4 | 0.00244 |
| Pllp | 1.6 ± 0.6 | 0.0175 |
| Mal | 1.8 ± 0.6 | 0.0178 |
| Plcb1 | 2.0 ± 0.3 | 0.0186 |
| Ugt8a | 1.7 ± 0.6 | 0.0190 |
| Cdkn1a | 1.7 ± 0.6 | 0.0192 |
| Bcl2l1 | 1.4 ± 0.5 | 0.0216 |
| Jam3 | 1.5 ± 0.6 | 0.0240 |
| Gnai1 | 1.1 ± 0.4 | 0.0245 |
| P2rx7 | 1.8 ± 0.7 | 0.0253 |
| Pla2g16 | 1.5 ± 0.6 | 0.0265 |
| Arhgef10 | 1.5 ± 0.6 | 0.0268 |
| Fa2h | 1.5 ± 0.6 | 0.0269 |
| Plcb4 | 0.9 ± 0.4 | 0.0295 |
| Cers2 | 1.4 ± 0.6 | 0.0299 |
| Gria3 | 1.1 ± 0.5 | 0.0333 |
| Pmp22 | 2.2 ± 0.9 | 0.0339 |
| Nf1 | 1.0 ± 0.4 | 0.0351 |
aFollowing Bonferroni correction for multiple comparisons, all P values equalled 1 except P = 0.0897 for Nqo1 and P = 0.193 for Gga1