Table 2.
JNJ-47965567 does not alter gene expression of microglia or astrocyte markers in SOD1G93A mice. RNA from spinal cords from end stage SOD1G93A mice was analysed by NanoString to determine the changes in gene expression in JNJ-47965567-treated mice relative to β-CD-treated mice (n = 6 mice per group)
| Gene | Log2 (fold change ± SEM) | Pa |
|---|---|---|
| Microglia | ||
| Itgam(Cd11b) | 0.6 ± 0.5 | 0.257 |
| P2ry12 | 0.2 ± 1.0 | 0.879 |
| Astrocytes | ||
| Aldh1l1 | 0.3 ± 0.5 | 0.520 |
| Gfap | 0.2 ± 0.9 | 0.816 |
aFollowing Bonferroni correction for multiple comparisons, all P values equalled 1