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. 2020 Apr 19;83:104327. doi: 10.1016/j.meegid.2020.104327

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Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 2 — The life cycle of SARS-CoV-2 in human lung cells. Coronavirus is most often transmitted by droplets while sneezing and coughing and its journey begins in the first days after infiltration from the upper respiratory tract. The spike proteins of SARS-CoV-2 binds to ACE2 receptors. The virion then releases RNA genome into the cell and translation of structural and non-structural proteins follows. ORF1a and ORF1ab are translated to produce pp1a and pp1ab polyproteins, which are cleaved by the proteases that are encoded by ORF1a to yield non-structural proteins. This is followed by assembly and budding into the lumen of the ERGIC. Virions are then released from the infected cell through exocytosis (Adnan Shereen et al., 2020). NSP, non-structural proteins; ACE2, Angiotensin-Converting Enzyme 2; Rough ER, Rough Endoplasmic Reticulum; ERGIC, Endoplasmic Reticulum Golgi Intermediate Compartment.