Fig. 1.

Cumulative incidence of hepatocellular carcinoma (a) according to the presence of cirrhosis (b) and age at the time of HBeAg seroclearance (c). The cumulative incidence of HCC was 1.5, 6.2, 10.0, and 11.5% at 1, 3, 5, and 8 years after HBeAg seroclearance, respectively (a). It was significantly higher in patients with cirrhosis than in those without cirrhosis (b). For patients that achieved HBeAg seroclearance before 30, 31–40, 41–50, and > 50 years of age, the cumulative incidence of HCC was 0, 5.2, 14.1, and 34.3%, respectively, at 8 years after HBeAg seroclearance (c). HCC, hepatocellular carcinoma. P values were determined using log-rank testing