Table III.
Disease Severity in Patients With Single and Co‐infections With Conventional (RSV, PIV‐3, Influenza A, Adenovirus) and Newly Recognized Viruses (Rhinovirus, hMPV, hBoV, hCoV‐NL63, and hCoV‐OC43)
| a: Patients with single infections | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| RSV (n = 60)a | PIV‐3 (n = 25) | Influenza A (n = 7) | Adenovirus (n = 7) | Rhinovirus (n = 109) | hMPV (n = 9) | hBoV (n = 9) | hCoV‐NL63 (n = 1) | hCoV‐OC43 (n = 3) | hCoV‐229E (n = 1) | |
| Hospitalized | 45 (75.0%) | 17 (68.0%) | 4 (57.1%) | 5 (71.4%) | 88 (80.7%) | 5 (55.6%) | 5 (55.6%) | 1 (100.0%) | 3 (100.0%) | 1 (100.0%) |
| ICU admission | 21 (35.0%) | 6 (24.0%) | 0 | 1 (14.3%) | 19 (17.4%) | 1 (11.1%) | 0 | 1 (100.0%) | 0 | 1 (100.0%) |
| Premature | 13 (21.7%) | 5 (20.0%) | 0 | 0 | 9 (8.3%) | 0 | 0 | 1 (100.0%) | 1 (33.3%) | 0 |
| Died | 6 (10.0%) | 1 (4.0%) | 0 | ? | 8 (7.3%) | 1 (11.1%) | 1 (11.1%) | 0 | 0 | 0 |
| HIV status | ||||||||||
| HIV negative | 9 (15.0%) | 2 (8.0%) | 4 (57.1%) | 1 (14.3%) | 12 (11.0%) | 1 (11.1%) | 1 (11.1%) | 0 | 0 | 1 (100.0%) |
| HIV sero‐positive | 38 (63.3%) | 13 (52.0%) | 3 (42.9%) | 2 (28.6%) | 69 (63.3%) | 4 (44.4%) | 5 (55.6%) | 1 (100.0%) | 3 (100.0%) | 0 |
| Unknown status | 13 (21.7%) | 10 (40.0%) | 0 | 4 (57.1%) | 28 (25.7%) | 4 (44.4%) | 3 (33.3%) | 0 | 0 | 0 |
| b: Patients with co‐infections | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| RSV (n = 70) | PIV‐3 (n = 15) | Influenza A (n = 11) | Adenovirus (n = 20) | Rhinovirus (n = 95) | hMPV (n = 20) | hBoV (n = 26) | hCoV‐NL63 (n = 12) | hCoV‐OC43 (n = 9) | hCoV‐229E (n = 1) | |
| Hospitalized | 39 (55.7%) | 11 (73.3%) | 7 (63.6%) | 15 (75.0%) | 55 (57.9%) | 15 (75.0%) | 19 (73.1%) | 9 (75.0%) | 7 (77.8%) | 0 |
| ICU admission | 12 (17.1%) | 2 (13.3%) | 1 (9.1%) | 1 (5.0%) | 1 (9.5%) | 1 (5.0%) | 2 (7.7%) | 3 (25.0%) | 0 | 1 (100.0%) |
| Premature | 3 (4.3%) | 0 | 1 (9.1%) | 0 | 3 (3.2%) | 0 | 0 | 0 | 0 | 0 |
| Died | 2 (2.9%) | 0 | 0 | 1(5%) | 5 5.2% | 1 (5.0%) | 2 (7.7%) | 1 (8.3%) | 0 | 0 |
| HIV status | ||||||||||
| HIV negative | 15 (21.4%) | 3 (20.0%) | 3 (27.3%) | 4 (20.0%) | 15 (15.8%) | 3 (15.0%) | 3 (11.5%) | 5 (41.7%) | 2 (22.2%) | 1 (100.0%) |
| HIV sero‐positive | 41 (58.6%) | 11 (73.3%) | 7 (63.6%) | 13 (65.0%) | 70 (73.7%) | 11 (55.0%) | 19 (73.1%) | 5 (41.7%) | 5 (55.6%) | 0 |
| Unknown status | 14 (20.0%) | 1 (6.7%) | 1 (9.1%) | 3 (15.0%) | 20 (21.1%) | 6 (30.0%) | 4 (15.4%) | 2 (16.6%) | 2 (22.2%) | 0 |
Conventional viruses parainfluenza 1, parainfluenza 2, and influenza B are not shown due to low prevalence; ICU, intensive care unit; N/D, not determined.
a
Additional information for 60/67 (89.6%) of hospitalized and outpatients with RSV single infections as identified by real‐time RT‐PCR were included in this analysis.