Table 1.
Definition of acid–base disorders using Henderson–Hasselbalch (H–H) and physicochemical (SID) approach.
| Approach | Type of Disorder | Parameter7, 27 | Acidosis | Alkalosis |
|---|---|---|---|---|
| H–H | Respiratory | p vCO2 [34–45 mmHg] | ↑pvCO2 | ↓p vCO2 |
| Metabolic | HCO3 − [20–30 mmol/L] | ↓HCO3 − | ↑HCO3 − | |
| AG <20 mmol/L | ↑AG | N/A | ||
| SID | Respiratory | p vCO2 [34–45 mmHg] | ↑p vCO2 | ↓p vCO2 |
| Metabolic | SID3 [38–44 mmol/L] | ↓SID3 | ↑SID3 | |
| Atot [19–25 mmol/L] | ↑Atot | ↓Atot | ||
| SIG [3 to −3 mmol/L] | ↓SIG | N/A |
Modified from Constable.11 p vCO2, partial carbon dioxide pressure; HCO3 −, bicarbonate; AG, anion gap; SID3, strong ion difference measured; SIG, strong ion gap; Atot, total plasma concentration of nonvolatile weak acids.
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